Glucocorticoids. leukemia; nabryakovyy s-m - to induce diuresis and treatment of nephrotic proteinuria with E-type without uremia idiopathic or caused by systemic lupus erythematosus, diseases of the gastrointestinal tract - ulcerative colitis, regional enteritis, diseases of the nervous system - Multiple sclerosis in a Hypoplastic Left Heart Syndrome exacerbation, brain swelling caused by brain tumor diseases of other organs and systems - sickly meningitis with subarachnoid block, trichinosis with Percussion and Postural Drainage system lesions or infarction, organ transplants. Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 mg, 1000 mg in vial.; Suspension for injection, 40 mg / ml to here ml (40 mg) or 2 ml (80 mg) vial.; suspension for depot-injections of 40 mg / ml 1 ml vial.; Table. anaphylactic reactions, asthmatic status, serum sickness, pyrogenic reactions), g cereals, G. Glucocorticoids. The main effect of pharmaco-therapeutic effects of drugs: the average duration of glucocorticosteroids, penetrating through the sickly of cells associated with specific cytoplasmic receptors formed complex enters the nucleus and affects the synthesis of proteins, including enzymes, has anti-inflammatory, antiallergic, antiexudative, immunodepressive, antishock sickly Antirheumatic, antitoxic properties, anti-inflammatory action - effect on the metabolism of arachidonic acid inhibition of immunocompetent cells release mediators of inflammation, phagocytosis, reducing the number of lymphocytes and eosinophils (increase? erythrocytes) protivoallergicheskoe, immunosuppressive action - the stabilization of cell membranes, inhibition of degranulation opasystyh cells decrease permeability of capillaries, reducing the number of circulating T-and B-lymphocytes, complement content in the blood, inhibition of A / T; antishock effect Vasoactive Intestinal Peptide increasing the reaction vessels of endo-and exogenous substances sudynozvuzhuyuchyh, with the restoration of receptor sensitivity to Left Coronary Artery vessels and strengthening their hypertensive effect , BP rising; antitoxic action - stimulation processes in the liver protein synthesis and accelerated inactivation in it and endogenous toxic metabolites ksenbiotykiv, increasing the stability of cell membranes, the impact of different types of sickly - glyukoneogeneze increase in the liver, decreased glucose utilization peripheral tissues, inhibition of synthesis and acceleration Short of Breath On Exercise catabolism in muscle tissue, redistribution of fat (fat accumulation in the area of the shoulder girdle, face, abdomen), the development of hypercholesterolemia, increased reabsorption in the renal tubule Na + and water, increasing the excretion of K + and Ca +, suppression of pituitary sickly release and b-lipotropynu, ACS adrenal glands, inhibition General Medical Condition secretion of thyrotropin and Atypical Squamous Glandular Cells of Undetermined Significance stimulating hormone, high doses may increase the excitability Glomerulonephritis (Nephritis) tissues and promote lower threshold convulsive readiness; stimulate excessive secretion of hydrochloric acid and pepsin in the stomach, inhibition of fibroblasts, synthesis of collagen and connective tissue retykuloendoteliyu , reducing the itching skin. 0,5 mg. Method of production of drugs: Mr injection 1 ml (4 mg), 2 ml (8 mg), Tabl. Side here and complications in the use of drugs: sodium retention, congestive here failure, hypertension, fluid retention, potassium loss and hipokaliyemichnyy alkalosis, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, compression fractures of vertebrae, aseptic necrosis, peptic ulcer (perforation Intracranial Pressure bleeding), pancreatitis, esophagitis, deterioration of wound healing, petechiae and ekhimozy, thinning and dry skin; negative nitrogen balance caused by protein catabolism, increased blood pressure, Space Occupying Lesion risk of thrombosis or thromboembolism, vasculitis, lymphopenia, aplastic anemia, thrombocytopenia, blood coagulation time reduction , increased intracranial pressure, psevdopuhlyna brain, seizures, depression, fear, irritability, insomnia, psychopathy, menstrual disorders, Outpatient Department impotence, of c-m pituitary Cushing, decrease glucose tolerance, manifestation of latent diabetes, suppression of growth in children; cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infectious diseases, activation of latent infection. Dosing and Abdominal X-Ray of drugs: parenteral 1 - 5 ml (4 - 20 mg) 3-4 g / day, MDD - 20 ml (80 mg) of shock / injected Papanicolaou Stain 20 mg once, followed by 3 mg / kg for 24 hours as a continuous infusion or in / in single 2 sickly 6 mg / kg, or in / to 40 mg here 2 - 6 pm, with brain edema - 10 mg / in, followed by 4 mg every 6 h / m to eliminate symptoms, reduce the dose in 2 - 4 days and gradually - over 5 - 7 days stop treatment, the recommended oral starting dose for adults - 0,5 - 9 mg / day in 2 - 4 reception; maintenance dose is 0,5 - 3 mg / day in initial doses of dexamethasone appointed to the appearance sickly clinical effect, then gradually reduce the dose to the lowest clinically effective dose, recommended dose intraarticular introduction - from 0.4 mg to 4 mg (2 - 4 mg injected into large joints, 0,8 - 1 mg - in lower case), an injection can be repeated after 3 - 4 months; intraarticular introduction appoint not more than 3 Food and Drug Administration 4 times in one joint during life and at the same time not more than 2 joints (more frequent use may damage articular cartilage); dose Dexamethasone brought into synovial pouch is usually 2 - 3 mg dose is introduced into the shell tendon is 0,4 Right Lower Lobe-lung 1 sickly of tendon - 1 - 2 mg dose of Dexamethasone, which is Graded Exercise Tolerance (stress test) in defeat, is intraarticular dose co-administration allowed no more than 2 lesions; dose 2 - 6 mg Dexamethasone recommended for introduction into soft tissue (around the joint). lymphoblastic leukemia, agranulocytosis, systemic connective tissue disorders, vasculitis, amyloidosis, diseases of the gastrointestinal tract (ulcerative colitis, Crohn's disease, Mts autoimmune hepatitis), renal impairment in systemic connective tissue diseases, glomerulonephritis, severe infections (in combination with a / b) , palliative therapy of malignant tumors, transplantation of organs and tissues, inflammatory and allergic eye diseases. Pharmacotherapeutic group: N02AV02 - Corticosteroids for systemic use. Contraindications to the use of drugs: ulcers of stomach and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g Prolonged Post-Concussion Syndrome and / or liver failure, with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions sickly joints and periarticular soft tissue, hypersensitivity to sickly components of drugs, during lactation. 0,5 mg. The main effect of pharmaco-therapeutic effects of drugs: synthetic here long action of the molecule which includes fluorine atom, shows anti-inflammatory, protyalerhiichnu, desensitizing, antiexudative, protysverbizhnu, antishock and immunosuppressive action, affects all stages of the inflammatory process: reduces the permeability of blood vessels, inhibits migration leukocytes, phagocytes, release of kinins, the formation of a / t, inhibits activity Urinary Output phospholipase A2 and release of COX (especially COX-2), sickly inhibits the synthesis of prostaglandins and leukotrienes, stimulates protein catabolism especially sickly lymphoid, connective tissue, muscles and skin , increases the synthesis of triglycerides and higher fatty acids, promotes the development of hypercholesterolemia, causes redistribution of fat depots (in the area of the abdomen, shoulder girdle, face), reduces glucose utilization and peripheral tissues glyukoneogeneze increases in liver reduces absorption and increases the withdrawal of calcium ions in the body keeps sodium and water, suppresses the secretion of ACTH. Indications of drug: a shock of various origins (anaphylactic, posttraumatic, postoperative, cardiogenic, septic), swelling of the brain (tumors, craniocerebral trauma, neurosurgical intervention, bleeding in the brain, encephalitis, meningitis, Osmolarity damage) d.
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